Development and Validation of Liquid Chromatography- Mass Spectroscopy/Mass Spectroscopy Method for Quantitative Analysis of Naproxen in Human Plasma after Liquid-Liquid Extraction
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منابع مشابه
Development and Validation of Liquid Chromatography- Mass Spectroscopy/Mass Spectroscopy Method for Quantitative Analysis of Naproxen in Human Plasma after Liquid-Liquid Extraction
Purpose: To determine naproxen levels in human plasma using a new liquid chromatography-Mass spectroscopy/Mass spectroscopy (LC-MS/MS) method that involves a simple and single step extraction procedure using low-cost reagents. Method: A novel liquid chromatography–tandem mass spectrometry method for the quantitative determination of naproxen in human K2-EDTA plasma in negative ion mode was empl...
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Extraction and determination of naproxen from human plasma were performed using Vortex-Assisted Inverted Dispersive Liquid-Liquid MicroExtraction (VA−IDLLME) and High-Performance Liquid Chromatography (HPLC). The parameters affecting extraction recovery such as type and volume of extraction and disperser solvents, pH of sample solution, stirring rate, extraction time and salt addition were ...
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ژورنال
عنوان ژورنال: Tropical Journal of Pharmaceutical Research
سال: 2014
ISSN: 1596-9827,1596-5996
DOI: 10.4314/tjpr.v13i9.17